Pyogenic arthritis, pyoderma gangrenosum, and acne

A hereditary autosomal dominant disorder characterized by pyogenic (infectious) arthritis, pyoderma gangrenosum, and severe cystic acne. Onset is in childhood; pyoderma gangrenosum; and severe cystic acne occur in adolescence and beyond. Other less common features may include adult-onset DIABETES MELLITUS, TYPE I; PROTEINURIA, ABSCESS formation at the site of parenteral injections, and cytopenias attributable to SULFONAMIDE medications. Mutations in the PSTPIP1 gene have been identified. OMIM: 604416

Also Known As:

Familial recurrent arthritis; PAPA syndrome; Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, and Acne; Pyogenic arthritis, pyoderma gangrenosum, and severe cystic acne

Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Skin Ulcer: 900
    - Pyoderma Gangrenosum: 1416
      - Pyogenic arthritis, pyoderma gangrenosum, and acne: 68
  - Pyoderma: 704
    - Pyoderma Gangrenosum: 1416
      - Pyogenic arthritis, pyoderma gangrenosum, and acne: 68
  - Vascular Skin Diseases: 528
    - Pyoderma Gangrenosum: 1416
      - Pyogenic arthritis, pyoderma gangrenosum, and acne: 68
  - Acneiform Eruptions: 196
    - Acne Vulgaris: 10473
      - Pyogenic arthritis, pyoderma gangrenosum, and acne: 68
  - Sebaceous Gland Diseases: 1
    - Acne Vulgaris: 10473
      - Pyogenic arthritis, pyoderma gangrenosum, and acne: 68
Infections: 526564
- Infectious Arthritis: 2095
  - Pyogenic arthritis, pyoderma gangrenosum, and acne: 68
Musculoskeletal Diseases: 719
- Joint Diseases: 6509
  - Arthritis: 33467
    - Infectious Arthritis: 2095
      - Pyogenic arthritis, pyoderma gangrenosum, and acne: 68

G Padalon-Brauch Selected Research

G Padalon-Brauch Research Topics

Disease

Drug/Important Bio-Agent (IBA)